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Most synthetic cannabinoids are here agonists in the cannabinoid receptors. They are already made to be much like THC,[9] the normal cannabinoid with the strongest binding affinity to your CB1 receptor, which happens to be linked to the psychoactive outcomes or "high" of marijuana.[ten] These synthetic analogs normally have greater binding affinity and bigger potency for the CB1 receptors.
Some early synthetic cannabinoids ended up also utilised clinically. Nabilone, a primary era synthetic THC analog, continues to be made use of as an antiemetic to fight vomiting and nausea considering the fact that 1981.
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